Core Adult Internal Medicine Disciplines

Clinical Immunology

Topics

• Structure and function of the cellular and humoral components of the immune system.
  
• The types of tissue injury mediated by cells with immune function, antibodies, immunological and inflammatory mediators such as cytokines, complement components, etc.
  
• Mechanisms of immune mediated disease, including patterns of immune deficiency, and immediate and delayed hypersensitivity.
  
• The mechanisms involved in the generation and control of immune responses to foreign proteins, allergens, microorganisms and autoantigens.
  
• Knowledge of immunogenetics, particularly the HLA system and its role in transplantation and disease association.
  
• Inpatient and outpatient experience in the diagnosis and management of primary and acquired immune deficiency disorders.
  
• Human immunodeficiency virus infection and its complications.
  
• Organ specific and multisystem autoimmune diseases (including relevant rheumatological disorders).
  
• Systemic vasculitides.
  
• Lymphoproliferative disorders and dysproteinaemias.
  
• Amyloidosis, sarcoidosis and immune complex disorders.
  
• Knowledge of the mechanisms of action, pharmacokinetics, efficacies and toxicities of currently used anti-inflammatory and immune-suppressive pharmaceuticals.
  
• Knowledge of the principles underlying plasmapheresis and desensitisation.

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